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Doctor Story Nepal - Insulin Shock Therapy (It was the treatment Insulin Shock Therapy ( It was the treatment of choice for schizophrenia and psychotic patient for over 20 years ) Insulin shock therapy or insulin coma therapy was a form of psychiatric treatment in which patients were repeatedly injected with large doses of insulin in order to produce daily comas over several weeks . It was introduced in 1927 by Austrian - American psychiatrist Manfred Sakel and used extensively in the 1940s and 1950s , mainly for schizophrenia , before falling out of favour and being replaced by neuroleptic drugs in the 1960s . It was one of a number of physical #treatments introduced into #psychiatry in the first four decades of the 20th century . These included the convulsive therapies ( cardiazol / metrazol therapy and electroconvulsive therapy ) , deep sleep therapy and psychosurgery . Insulin shock therapy or insulin coma therapy was a form of psychiatric treatment in which patients were repeatedl